Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal-Organic Framework Composite Piezoelectric Nanofibers for Wireless Tumor Treating Fields Therapy.

ACS biomaterials science & engineering·2026
Same author

Layer-by-Layer Surface-Modified Supramolecular Fullerene Microrods for Cell Feeding.

ACS applied materials & interfaces·2026
Same author

Reprogrammable shape memory ion gels <i>via</i> physical entanglement of ultrahigh molecular weight polymers.

Materials horizons·2026
Same author

Correction: Mano et al. Fluidity of Poly (ε-Caprolactone)-Based Material Induces Epithelial-to-Mesenchymal Transition. <i>Int. J. Mol. Sci.</i> 2020, <i>21</i>, 1757.

International journal of molecular sciences·2026
Same author

Oriented Micropore-Forming Bioinks for 3D Bioprinting of Muscle Tissues.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Magnetic Induction Heating Enables On-Demand Drug Release via Diels-Alder Polymeric Nanocarriers.

Biomacromolecules·2025

Related Experiment Video

Updated: Feb 25, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

14.1K

An Intriguing Method for Fabricating Arbitrarily Shaped "Matreshka" Hydrogels Using a Self-Healing Template.

Takeshi Sato1,2,3, Koichiro Uto4, Takao Aoyagi5

  • 1Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan. SATOU.Takeshi@nims.go.jp.

Materials (Basel, Switzerland)
|August 5, 2017
PubMed
Summary

Researchers created custom-shaped hydrogels using a novel self-healing template (SHT) method. This technique allows for precise shaping and fabrication of complex 3D structures for potential cell manipulation applications.

Keywords:
biocompatible polymerhydrogel fabricationself-healing material

More Related Videos

Fabrication of Micropatterned Hydrogels for Neural Culture Systems using Dynamic Mask Projection Photolithography
16:06

Fabrication of Micropatterned Hydrogels for Neural Culture Systems using Dynamic Mask Projection Photolithography

Published on: February 11, 2011

19.4K
Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

15.7K

Related Experiment Videos

Last Updated: Feb 25, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

14.1K
Fabrication of Micropatterned Hydrogels for Neural Culture Systems using Dynamic Mask Projection Photolithography
16:06

Fabrication of Micropatterned Hydrogels for Neural Culture Systems using Dynamic Mask Projection Photolithography

Published on: February 11, 2011

19.4K
Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

15.7K

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Polymer Chemistry

Background:

  • Hydrogels are versatile biomaterials with applications in drug delivery, tissue engineering, and regenerative medicine.
  • Fabricating hydrogels with precise, arbitrary shapes remains a significant challenge in materials science.
  • Existing methods often lack the flexibility to create complex, hierarchical structures.

Purpose of the Study:

  • To develop a novel and versatile method for fabricating arbitrarily shaped hydrogels.
  • To demonstrate the capability of the self-healing template (SHT) system for creating complex 3D structures.
  • To explore the potential applications of SHT-fabricated hydrogels in cell manipulation.

Main Methods:

  • Utilized a self-healing template (SHT) loaded with photo-crosslinkable monomers, specifically polyethylene glycol diacrylate (PEGDA).
  • Shaped the monomer-loaded SHT using ultraviolet (UV) light crosslinking.
  • Removed the SHT via simple water washing to yield the final hydrogel structure.
  • Repeated the self-healing and photo-irradiation process to create hierarchical 3D structures, such as 'Matreshka' boxes.

Main Results:

  • Successfully fabricated hydrogels in desired, arbitrary physical shapes.
  • Demonstrated the creation of complex hierarchical 3D structures by repeating the SHT process.
  • Confirmed the removal of the SHT by water washing without damaging the hydrogel structure.
  • Explored and validated the potential of the SHT system for cell manipulation.

Conclusions:

  • The self-healing template (SHT) offers an effective and adaptable strategy for the precise fabrication of arbitrarily shaped hydrogels.
  • This method enables the construction of intricate, hierarchical 3D structures with potential applications in advanced biomaterials and cell-based technologies.
  • The SHT system presents a promising platform for future developments in tissue engineering and regenerative medicine.