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[Association between S100B gene polymorphisms and hand, foot and mouth disease caused by enterovirus 71 infection]
Jing Li1, Ruo-Bing Shan, Rui-Hai Liu
1Department of Pediatric Intensive Care Unit, Critical Care Medicine Center, Women and Children's Hospital, Qingdao University, Qingdao, Shandong 266000, China. lisang1976@aliyun.com.
Insights
The T allele in the S100B gene rs9722 locus is linked to severe hand, foot, and mouth disease (HFMD) from enterovirus 71. This genetic factor may increase disease severity and indicate a poorer prognosis in affected children.
Area of Science:
- Genetics
- Virology
- Molecular Biology
Background:
- Hand, foot, and mouth disease (HFMD) is a common infectious illness in children.
- Enterovirus 71 (EV71) is a major causative agent of severe HFMD.
- The S100B gene's role in EV71-induced HFMD is not fully understood.
Purpose of the Study:
- To investigate the association between S100B gene rs9722 polymorphisms and EV71-caused HFMD.
- To determine if rs9722 polymorphisms correlate with HFMD severity and prognosis.
Main Methods:
- Case-control study involving 124 children with EV71 HFMD and 56 healthy controls.
- Genotyping of S100B gene rs9722 polymorphisms.
- Measurement of serum S100B protein levels in HFMD patients.
Main Results:
- The TT genotype and T allele of S100B rs9722 were significantly more frequent in HFMD patients than controls.
- Severe HFMD cases showed higher frequencies of the TT genotype and T allele compared to mild/moderate cases.
- Patients with poor prognosis had increased frequencies of the TT genotype and T allele.
- Serum S100B protein levels were highest in TT genotype individuals and lowest in CC genotype individuals.
Conclusions:
- The T allele at the S100B rs9722 locus may serve as a genetic risk factor for severe EV71-induced HFMD.
- S100B rs9722 genotype is associated with disease severity and prognosis in EV71 HFMD.
- Elevated serum S100B protein levels correlate with the TT genotype.
Objective:
To investigate the association between rs9722 polymorphisms in the S100B gene and hand, foot and mouth disease (HFMD) caused by enterovirus 71.
Methods:
A total of 124 HFMD children with enterovirus 71 infection were enrolled as subjects, and 56 healthy children were enrolled as control group. The rs9722 polymorphisms in the S100B gene were detected for both groups, and the serum level of S100B protein was measured for 74 HFMD children.
Results:
The rs9722 locus of the S100B gene had three genotypes, CC, CT, and TT, and the genotype frequencies were in accordance with Hardy-Weinberg equilibrium. Compared with the control group, the HFMD group had significant increases in the frequencies of TT genotype and T allele (P<0.01). Children with severe HFMD caused by enterovirus 71 infection had significantly higher frequencies of TT genotype and T allele than those with moderate or mild HFMD (P<0.05). Compared with the cured patients, the patients with poor prognosis had significant increases in the frequencies of TT genotype and T allele in the rs9722 locus of the S100B gene (P<0.05). Among the 74 children with HFMD, the children with TT genotype had the highest serum level of S100B protein, and those with CC genotype had the lowest level (P<0.01).
Conclusions:
T allele in the rs9722 locus of the S100B gene might be a risk factor for severe HFMD caused by enterovirus 71 infection.
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