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Updated: Feb 25, 2026

2 in 1: One-step Affinity Purification for the Parallel Analysis of Protein-Protein and Protein-Metabolite Complexes
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Small-Molecule Modulation of Protein Homeostasis

George M Burslem1, Craig M Crews1

  • 1Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University , 219 Prospect Street, New Haven, Connecticut 06511, United States.

Chemical Reviews
|August 5, 2017
PubMed
Summary

Small molecules offer advantages over nucleic-acid-based technologies for controlling intracellular protein levels. This review compares small-molecule systems for protein regulation, highlighting their therapeutic potential.

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