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The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2

Yulong Li1, Hongyan Wang1,2, Xiu Jun Wang2

  • 1Department of Biochemistry, Zhejiang University School of Medicine, Hangzhou, China.

FEBS Letters
|August 5, 2017
PubMed

Insights

The short isoform of PML-RARα (PR-S) enhances the activity of the cytoprotective NRF2 pathway. This novel function of PR-S as a NRF2 transcriptional co-activator was discovered in acute promyelocytic leukemia research.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Oncology

Background:

  • The NF-E2 p45-related factor 2 (NRF2) pathway is crucial for cellular protection.
  • Acute promyelocytic leukemia involves the PML-RARα (PR) oncogene.
  • Previous research indicated RARα and PML inhibit NRF2, but PR's effect was unknown.
Keywords:
APLNRF2PML-RARα

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