Related Experiment Video
Updated: Feb 25, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
The Immune Basis of Narcolepsy: What Is the Evidence?
1Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine Qatar, Qatar Foundation-Education City, PO Box 24144, Doha, Qatar.
Abstract:
Narcolepsy is a chronic neurologic sleep disorder. Type 1 narcolepsy (narcolepsy-cataplexy) is associated with the destruction of lateral hypothalamic hypocretin neurons. It is thought that the loss of hypocretin neurons is autoimmune mediated. This is because of the close relationship between type 1 narcolepsy and HLA DQB1∗0602 and the onset of narcolepsy at a young age. Evidence suggests that streptococcal and H1N1 influenza infections (and H1N1 vaccination) may be involved in the pathogenesis of narcolepsy. There are suggestions from genetic and immune studies that the immune system plays a key role in narcolepsy.
Related Concept Videos
Narcolepsy
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Introduction to Biological Bases of Psychology
The nervous system, the cornerstone of...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...

