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Updated: Feb 25, 2026

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
Published on: July 29, 2022
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease
E Caggiu1, K Paulus2, G Galleri2
1Dipartimento di Scienze Biomediche, Sezione di Microbiologia, Università di Sassari, Italy.
Abstract:
Environmental factors are implicated in the development of Parkinson's disease (PD). The aim of this study is to investigate the role of cell-mediated immunity upon a specific immune-stimulation with HSV-1 and human alpha-synuclein homologues peptides by using the intracellular cytokine method on Parkinson's patients and healthy controls. The study showed, for the first time, a specific response to TNF-α CD8, CD4 and NK cells after stimulation in PD patients. Our data show a possible role of the immune system in the pathogenesis of Parkinson's disease, and that HSV-1 infections may lead to a progression of the disease.
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