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Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1

Chan Woo Kim1, Anastassia Pokutta-Paskaleva1, Sandeep Kumar1

  • 1From Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta (C.W.K., A.P.-P., S.K., D.-W.K., J.R., R.L.G., H.J., L.P.B.); Department of Microbiology, College of Medicine, Inha University, Incheon, Republic of Korea (C.W.K.); Department of Surgery, Emory University, Atlanta, GA (A.P.-P., A.D.M., T.C., K.M.K., H.L., L.P.B.); Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA (L.H.T.); Department of Bioengineering, University of Utah, Salt Lake City (L.H.T.); Mercer University School of Medicine, Macon, GA (S.D.); Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan (H.Y.); George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta (R.L.G.); Surgical and Research Services, Atlanta VA Medical Center, Decatur, GA (L.P.B.); and Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta (L.P.B.).

Circulation
|August 6, 2017
PubMed
Summary

Disturbed flow (d-flow) causes arterial stiffening by increasing collagen deposition, mediated by thrombospondin-1 (TSP-1) activating transforming growth factor-β pathways. Targeting TSP-1 may offer new therapies for arterial stiffening.

Keywords:
disturbed flowthrombospondinsvascular stiffness

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