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Evaluation of Sézary cell marker expression and cell death behaviour upon in vitro treatment by flow cytometry in Sézary syndrome patients.

Experimental dermatology·2024
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[Nuclear medicine procedure guideline for sentinel lymph node localization].

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Health-related quality of life and its influencing factors in patients with primary cutaneous B-cell lymphomas: A multicentric study in 100 patients.

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[Recent improvements in diagnosis and therapy of cutaneous T cell lymphomas].

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[Cutaneous squamous cell carcinoma].

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[Diagnostics of primary cutaneous lymphomas].

M Felcht1, U Hillen2, C-D Klemke3

  • 1Klinik für Dermatologie, Venerologie und Allergologie, UMM - Universitätsmedizin Mannheim Medizinische Fakultät Mannheim, Ruprechts-Karls-Universität Heidelberg, Exzellenzzentrum für Dermatologie des Landes Baden-Württemberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. Moritz.Felcht@umm.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|August 6, 2017
PubMed
Summary

Diagnosing Sézary syndrome, a type of cutaneous T-cell lymphoma, is challenging due to early-stage similarities with reactive erythroderma. New molecular markers show promise but require further validation for routine clinical use.

Keywords:
HistologyImmunohistologyMarkerReactive erythrodermaSézary syndrome

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Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous lymphomas can be challenging to diagnose, especially in early stages.
  • Sézary syndrome often presents diagnostic difficulties, mimicking reactive erythroderma.
  • Accurate diagnosis is crucial for effective treatment of cutaneous lymphomas.

Purpose of the Study:

  • To review the diagnostic challenges of Sézary syndrome.
  • To summarize clinical heterogeneity and diagnostic criteria for Sézary syndrome.
  • To discuss recent advancements in Sézary cell detection and potential new biomarkers.

Main Methods:

  • Review of clinical, histological, and immunohistochemical features of Sézary syndrome.
  • Analysis of data from European Organisation for Research and Treatment of Cancer (EORTC) multicenter studies.
  • Evaluation of molecular and cytogenetic characterization of tumor cells and potential diagnostic markers.

Main Results:

  • Sézary syndrome diagnosis is complicated by its heterogeneity and overlap with other conditions.
  • Detection of Sézary cells in blood remains challenging despite advanced techniques.
  • New markers (CD158k, MYC, MNT, DNM, TWIST1, EPHA4, PLS3) show potential for differentiating Sézary syndrome from reactive erythroderma.

Conclusions:

  • Accurate diagnosis of Sézary syndrome requires a comprehensive approach integrating clinical, histological, and molecular data.
  • Further research is needed to validate novel biomarkers for routine clinical application in Sézary syndrome diagnosis.
  • Improved diagnostic tools are essential for timely and accurate management of Sézary syndrome.