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Updated: Oct 17, 2026

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
Published on: March 2, 2012
Separation and determination of isopropamide iodide in pharmaceutical formulations by reversed-phase ion-pair
Abstract:
A stability-indicating determination for isopropamide iodide, an anticholinergic quaternary ammonium drug, in several pharmaceutical dosage forms by reversed-phase ion-pair liquid chromatography is reported. The use of eluents containing both an amine as well as an alkylsulphonate proved to be very efficient for separating and determining quaternary ammonium drugs and related other basic drugs: adequate selectivity, excellent peak shape and good reproducibility (coefficient of variation, 1-2%) were obtained in a short analysis time.
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