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A Continuous, Long-Term Plasmodium vivax In Vitro Blood-Stage Culture: What Are We Missing?
Richard Thomson-Luque1, Katy Shaw Saliba2, Clemens H M Kocken3
1Center for Global Health & Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, FL, USA.
Abstract:
The recent research efforts to establish a Plasmodium vivax continuous, long-term blood-stage culture have focused on the ideal host cell type. However, this is only part of the story, as the P. vivax intraerythrocytic life cycle is complex. A successful, long-term, robust culture system will depend on a multifaceted approach combining the ideal cell type and parasite isolates, and the culture conditions.
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