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Updated: Feb 25, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Sudden onset flank pain: Spontaneous renal rupture
Seth M Grubb1, Jonathan I Stuart1, Hillary M Harper1
1Darnall Army Medical Center, 36065 Sante Fe Ave., Fort Hood, TX 76544, United States.
Wunderlich's syndrome, a rare cause of atraumatic renal rupture, can present as undifferentiated abdominal pain in young adults. Prompt recognition and understanding of this condition are crucial for effective emergency department management and improved patient outcomes.
Area of Science:
- Emergency Medicine
- Nephrology
- Radiology
Background:
- Undifferentiated abdominal pain is a frequent emergency department presentation.
- Atypical presentations of serious conditions can occur in young, healthy individuals.
- Risk stratification typically relies on patient demographics and comorbidities.
Observation:
- A case vignette details a 22-year-old male with spontaneous, atraumatic renal rupture.
- The patient presented with a large retroperitoneal hemorrhage, indicative of Wunderlich's Syndrome.
- This syndrome represents an uncommon etiology of abdominal pain.
Findings:
- Wunderlich's Syndrome is a rare diagnosis characterized by spontaneous, atraumatic renal rupture.
- Retroperitoneal hemorrhage is a key finding in this condition.
- Early recognition is vital for appropriate patient disposition.
Implications:
- Understanding Wunderlich's Syndrome aids emergency physicians in diagnosing uncommon abdominal pain causes.
- Knowledge of risk factors and presentations improves patient management and outcomes.
- This case highlights the importance of considering rare diagnoses in emergency settings.
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