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Updated: Feb 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Practical Application of Evidence-Based Practice
1Small Animal Surgery, Department of Surgical and Radiological Sciences, Davis School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA.
Abstract:
High-quality clinical practice requires veterinarians to stay abreast of new research and integrate relevant findings into patient care. Clinicians can achieve this goal using evidence-based practice (EBP), the stepwise process of integrating best research evidence into existing clinical decision-making processes. This article provides explanations and recommendations for performing key steps of the EBP process, with a focus on issues the exotic animal practitioner might encounter. Key areas of discussion include the development of focused PICO questions, types of literature and search strategies, and basic clinical epidemiology principles, including chance error, bias, confounding, and generalizability.
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