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Dissecting Glioma Invasiveness in a 3D-Organotypic Model
Paolo Codega1, Ingo K Mellinghoff2
1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Trends in Molecular Medicine
|August 8, 2017
Abstract:
Diffuse brain infiltration by tumor cells is a hallmark of glioma. Molecular mechanisms of brain invasion are poorly understood due to the difficulty to model this process in culture. A new study published in Cell Reports developed a three-dimensional organotypic model and identified interferon regulatory factor 3 (IRF3) as repressor of glioma invasion.
