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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Diagnosis and treatment of inherited thrombophilia

Eriko Morishita1

  • 1Department of Clinical Laboratory Medicine, Kanazawa University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|August 8, 2017
PubMed

Inherited thrombophilia is a thrombotic diathesis caused by a variety of genetic abnormalities in anticoagulant factors such as antithrombin (AT), protein C (PC), and protein S (PS), or coagulation factors such as prothrombin and factor V. Patients with inherited thrombophilia often present with unusual clinical episodes of venous thromboembolism (VTE), which manifests as deep vein thrombosis or pulmonary thromboembolism in young persons (younger than 40 years), often with a positive family history of thrombosis. Moreover, the thrombosis sometimes recurs, despite anticoagulant therapy. The genetic background is known to differ between Caucasians and East Asians. Starting this April, inherited thrombophilia, AT, PC, or PS deficiency, are officially designated as intractable diseases, and the treatment of these diseases is subsidized as public expense.

Keywords:
AntithrombinProtein CProtein SThrombophilia

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