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Heart Valves

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

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Related Experiment Video

Updated: Feb 25, 2026

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

Current Challenges in Translating Tissue-Engineered Heart Valves.

O M J A Stassen¹, D E P Muylaert², C V C Bouten^3,4

¹Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands. o.m.j.a.stassen@tue.nl.

Current Treatment Options in Cardiovascular Medicine

|August 8, 2017

Summary

This summary is machine-generated.

Tissue-engineered heart valves offer a promising alternative to valve replacement. Advanced bioreactors and in vitro models are key to overcoming challenges in developing these living heart valves for clinical use.

Keywords:

Heart disease Tissue-engineered heart valves Valvular heart disease

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Last Updated: Feb 25, 2026

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

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Published on: July 23, 2014

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Published on: October 17, 2013

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

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Published on: March 23, 2022

Area of Science:

Biomedical Engineering
Regenerative Medicine
Cardiovascular Research

Background:

Heart valve disease affects millions, with over 300,000 valve replacements annually.
Current valve replacement methods, while lifesaving, have associated complications.
Tissue-engineered heart valves (TEHVs) present a novel alternative, aiming for in situ regeneration.

Purpose of the Study:

To identify and address the key challenges hindering the clinical translation of TEHVs.
To explore the potential of advanced in vitro models in overcoming these obstacles.

Main Methods:

Utilizing novel in vitro models (bioreactors) for controlled culture of complex cell populations.
Investigating multidimensional and multiscalar challenges in TEHV development.

Main Results:

Challenges include patient variability, in vivo tissue conversion, mechanical demands, and achieving homeostatic tissue.
Optimizing both macroscopic valve properties and microscopic cell-material interactions is crucial.

Conclusions:

Advanced bioreactors and in vitro models are essential tools for overcoming TEHV development challenges.
These models facilitate the controlled study of cell populations and material properties for successful TEHV regeneration.