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Big Data and Genome Editing Technology: A New Paradigm of Cardiovascular Genomics

Chayakrit Krittanawong1, Tao Sun2, Eyal Herzog3

  • 1Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, 1000 10th Ave, New York, NY 10019. United States.

Current Cardiology Reviews
|August 8, 2017
PubMed

Insights

Genome-editing technologies offer new therapeutic strategies for cardiovascular diseases (CVDs) by precisely modifying DNA. These advanced techniques hold promise for correcting genetic defects and developing novel CVD treatments.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Molecular Biology

Background:

  • Cardiovascular diseases (CVDs) are a diverse group of conditions with complex and often poorly understood genetic underpinnings.
  • While genetic factors play a role in various CVDs, their precise mechanisms remain a significant challenge in clinical care.

Purpose of the Study:

  • To explore the impact of genome-editing technologies on understanding and treating cardiovascular diseases.
  • To discuss the potential of gene-editing tools in addressing the genetic basis of CVDs.

Main Methods:

  • Review of current literature on genome-editing technologies, including zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9 systems.
  • Analysis of genetic polymorphisms and mechanistic insights relevant to cardiovascular disease pathogenesis.
  • Discussion of the application of site-specific genome engineering in a therapeutic context.

Main Results:

  • Genome-editing technologies enable precise modification of DNA sequences for therapeutic purposes, such as correcting disease-causing variants or adding therapeutic genes.
  • These technologies offer novel opportunities for developing targeted therapies for cardiovascular diseases.
  • The potential applications range from correcting inherited cardiac conditions to addressing acquired forms of CVD.

Conclusions:

  • Genome editing represents a transformative approach in cardiovascular medicine, offering new avenues for therapeutic intervention.
  • Further research and development are crucial to overcome current challenges and fully realize the future prospects of genome editing in cardiovascular clinical care.

Keywords:
GWASGenome editing technologygenomegenome engineeringgenome-wide association studies

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