Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Religiosity and sexuality: A person- and couple-based approach.

Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)·2026
Same author

Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial.

JAMA internal medicine·2026
Same author

Aligning management of chronic cough in asthma with BTS/NICE/SIGN guidance.

Thorax·2026
Same author

Food environments provide availability and physical access to vegetables in urban Benin and Mali.

Public health nutrition·2025
Same author

Bioactive peptoids against vector-borne parasitic diseases.

Bioorganic & medicinal chemistry letters·2025
Same author

Erratum to "Role of Fusobacterium nucleatum in the pathogenesis of oral squamous cell carcinoma: A systematic review of molecular mechanisms and signalling pathways" [Archives of Oral Biology 179 (2025) 106369].

Archives of oral biology·2025

Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.9K

Cough sensors from dental pulp.

Lorcan P McGarvey1, Rebecca Clarke1, Fionnuala T Lundy1

  • 1Centre for Experimental Medicine, Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, Northern Ireland, United Kingdom.

Pulmonary Pharmacology & Therapeutics
|August 8, 2017
PubMed
Summary

Human dental pulp stem cells can become sensory neurons, offering a new in vitro model for studying conditions like chronic pain and cough. This research addresses challenges in accessing human sensory neurons for experimental study.

Keywords:
Airway sensory nervesCoughHuman dental pulp stem cells

More Related Videos

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.9K
A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals
08:06

A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals

Published on: February 14, 2020

6.6K

Related Experiment Videos

Last Updated: Feb 25, 2026

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.9K
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

11.9K
A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals
08:06

A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals

Published on: February 14, 2020

6.6K

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Translational Medicine

Background:

  • Altered sensory neural activity, particularly nerve hyperexcitability, is central to chronic cough, itch, and pain.
  • Studying human sensory neurons is difficult due to the inaccessibility of peripheral neuronal ganglia via biopsy.
  • Existing animal models present interspecies differences, highlighting the need for human-based in vitro models.

Purpose of the Study:

  • To investigate the potential of human dental pulp stem cells (hDPSCs) to differentiate into functional sensory neurons.
  • To evaluate the utility of hDPSCs as a novel in vitro model for studying sensory neural function.
  • To explore mechanisms underlying altered sensory neural activity in common clinical syndromes.

Main Methods:

  • Human dental pulp stem cells were cultured and induced to differentiate.
  • Neuronal differentiation was assessed using specific cell markers and electrophysiological techniques.
  • The model's capacity to mimic aspects of sensory neuron hyperexcitability was evaluated.

Main Results:

  • Human dental pulp stem cells demonstrated a propensity to differentiate into cells with neuronal characteristics.
  • Differentiated cells exhibited electrophysiological properties consistent with sensory neurons.
  • The model showed potential for investigating mechanisms of sensory nerve hyperexcitability.

Conclusions:

  • Human dental pulp stem cells represent a promising source for developing in vitro models of human sensory neurons.
  • This novel model system facilitates the study of sensory neural pathophysiology, including conditions like chronic pain and cough.
  • The development of such human-based in vitro models is crucial for advancing our understanding and treatment of neurological disorders.