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The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit
Eunjoo Kim1, Dong-Ho Song2, Nam-Wook Kim2
1Department of Psychiatry and Institute of Behavioral Science in Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Objective:
This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD).
Methods:
Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance.
Results:
We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing.
Conclusion:
Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
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