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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Related Experiment Video

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In Vivo Mouse Model of Spinal Implant Infection
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A spinal infection with Staphylococcus pseudintermedius.

Christopher A Darlow1, Nikolaos Paidakakos2, Murtuza Sikander2

  • 1Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

BMJ Case Reports
|August 9, 2017
PubMed
Summary
This summary is machine-generated.

This case report details a rare invasive spinal infection caused by Staphylococcus pseudintermedius, a bacterium typically found in animals. Prompt treatment, similar to Staphylococcus aureus infections, led to successful recovery.

Keywords:
bone and joint infectionsmedical managementneurosurgeryspinal cord

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Case Report

Background:

  • Spinal infections can be severe and challenging to treat.
  • Staphylococcus pseudintermedius is an emerging pathogen with zoonotic potential.
  • The identification of microorganisms is crucial for effective treatment.

Observation:

  • A 60-year-old woman presented with an invasive spinal infection linked to a long-standing spinal fixation device and contact with dogs.
  • Blood and epidural abscess pus cultures confirmed Staphylococcus pseudintermedius.
  • The patient developed a deep abscess, a previously unreported presentation for this organism.

Findings:

  • The infection was successfully treated with a regimen of intravenous flucloxacillin followed by oral clindamycin, mirroring treatment protocols for Staphylococcus aureus infections.
  • Matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) technology facilitated the specific identification of Staphylococcus pseudintermedius.
  • This case is the first reported instance of a deep abscess caused by Staphylococcus pseudintermedius.

Implications:

  • Staphylococcus pseudintermedius poses a zoonotic risk and can cause invasive infections in humans.
  • Standard treatment protocols for Staphylococcus aureus infections appear effective against Staphylococcus pseudintermedius.
  • Advances in microbial identification techniques are revealing previously unrecognized pathogens and their clinical significance.