Related Experiment Video

Updated: Feb 25, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

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BET Inhibitors as Anticancer Agents: A Patent Review

Imran Ali1, Gildon Choi1, Kwangho Lee1

  • 1Bio-Organic Science Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea.

Recent Patents on Anti-Cancer Drug Discovery
|August 9, 2017
PubMed
Abstract

Insights

Bromodomain and Extra Terminal (BET) inhibitors show promise as cancer therapeutics. This review covers BET inhibitor patent literature from 2010-2017, highlighting clinical development for various cancers.

Area of Science:

  • Epigenetics
  • Pharmacology
  • Oncology

Background:

  • Bromodomain and Extra Terminal (BET) proteins (BRD2, BRD3, BRD4, BRDT) are emerging cancer targets.
  • Small-molecule drug discovery is actively exploring BET proteins.

Purpose of the Study:

  • Review patent literature on BET inhibitors from 2010-2017.
  • Focus on cancer treatment and related diseases.

Main Methods:

  • BET proteins function as 'epigenetic readers' binding to acetylated histones.
  • Inhibition of BET proteins drives therapeutic applications and inhibitor development.

Main Results:

  • Significant patent activity from academia and industry on BET inhibitors.
  • Multiple BET inhibitors are in clinical development for diverse cancers.

Conclusions:

  • The review addresses unmet needs and challenges in BET inhibition for cancer.
  • Provides insights into current developments and future prospects of BET inhibitors.
Keywords:
BETBET inhibitorsBRDscancerepigeneticspatenttherapeutic potential.

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