Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Formation by Intramembranous Ossification

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Usability of an Artificial Intelligence-Enhanced Multispectral Imaging Tool for Burn Assessment: A Multi-Centre Retrospective Heuristic Evaluation.

Journal of burn care & research : official publication of the American Burn Association·2026

Same author

Acceptability of ambulance-based telemedicine (ABT) for paediatric emergencies in Karachi, Pakistan.

BMJ global health·2026

Same author

Acid and Alkali Chemical Assault Burns (Vitriolage): A Systematic Review of Epidemiology.

Plastic and reconstructive surgery. Global open·2025

Same author

Periodontal precision: diagnostic skills and confidence of dentists in Asian countries in applying the 2017 EFP/AAP periodontal disease classification- a cross-sectional pilot study.

BMC oral health·2025

Same author

Controlling Enzymatic Degradation of Carboxyl-Modified Chitosan and Hyaluronic Acid Biopolymers Using Dynamic Covalent Cross-Linking.

ACS applied bio materials·2025

Same author

Engineering bone repair with K21-Infused brushite cement: In-vitro and in-vivo insights.

Journal of dentistry·2025

Search research articles

Related Experiment Video

Updated: Feb 25, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers.

Zeeshan Sheikh¹, Mohammad Ahmad Javaid², Nader Hamdan³

¹Faculty of Dentistry, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada. zeeshan.sheikh@utoronto.ca.

Materials (Basel, Switzerland)

|August 10, 2017

Summary

Bone morphogenetic proteins (BMPs) show promise for enhancing bone healing and regeneration. This review explores their role and the use of biomaterial carriers for effective delivery in preclinical and clinical settings.

Keywords:

BMPs biomaterials bone morphogenetic proteins bone regeneration carrier methods

More Related Videos

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Related Experiment Videos

Last Updated: Feb 25, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedic Surgery

Background:

Bone fractures and defects often require bone grafting for healing.
Bone morphogenetic proteins (BMPs) are key molecules in bone regeneration.
Over 20 BMP types exist, with a subset capable of inducing new bone formation.

Purpose of the Study:

To introduce bone morphogenetic proteins (BMPs).
To discuss advances in preclinical and clinical applications of BMPs for bone regeneration.
To review the use of biomaterial carriers for BMP delivery.

Main Methods:

Literature review of preclinical and clinical studies on BMPs.
Analysis of BMP mechanisms in osteogenic differentiation.
Evaluation of biomaterial carriers for local BMP delivery.

Main Results:

BMPs effectively induce differentiation of stem cells into osteogenic cells.
Specific BMPs are capable of stimulating de novo bone formation.
Biomaterial carriers enhance the efficacy of local BMP delivery.

Conclusions:

BMPs are highly promising for enhancing bone healing and regeneration.
Biomaterial-based local delivery systems are crucial for optimizing BMP applications.
Further research and clinical translation are warranted for advanced bone defect management.