Radial distribution function of semiflexible oligomers with stretching flexibility

The radial distribution of the end-to-end distance R_ee is crucial for quantifying the global size and flexibility of a linear polymer. For semiflexible polymers, several analytical formulas have been derived for the radial distribution of R_ee ignoring the stretching flexibility. However, for semiflexible oligomers, such as DNA or RNA, the stretching flexibility can be rather pronounced and can significantly affect the radial distribution of R_ee. In this study, we obtained an extended formula that includes the stretch modulus to describe the distribution of R_ee for semiflexible oligomers on the basis of previous formulas for semiflexible polymers without stretching flexibility. The extended formula was validated by extensive Monte Carlo simulations over wide ranges of the stretch modulus and persistence length, as well as all-atom molecular dynamics simulations of short DNAs and RNAs. Additionally, our analyses showed that the effect of stretching flexibility on the distribution of R_ee becomes negligible for DNAs longer than ∼130 base pairs and RNAs longer than ∼240 base pairs.