Bone Morphogenetic Protein Coating on Titanium Implant Surface: a Systematic Review.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Dental Implantology

Background:

• Osseointegration is crucial for dental implant success.
• Titanium implants are widely used, but enhancing their integration remains a focus.
• Bone morphogenetic proteins (BMPs) show potential in promoting bone healing.

Purpose of the Study:

• To systematically review studies on improving osseointegration via BMP coating on titanium implants.
• To analyze the effects of BMP concentration, delivery systems, and adverse reactions.
• To evaluate BMP's influence on bone and peri-implant surfaces in vivo.

Main Methods:

• Systematic literature search of MEDLINE (PubMed) and EMBASE databases.
• Inclusion of articles published between October 2006 and September 2016 in English.
• Analysis of 8 selected articles focusing on BMP concentration, delivery, and effects, involving 340 implants and 236 models.

Main Results:

• BMP coating generally increases bone regeneration around titanium implants.
• Data analyzed included BMP concentration, delivery systems, and in vivo effects.
• Selected studies involved a significant number of implants and models for analysis.

Conclusions:

• BMP significantly enhances bone regeneration for improved osseointegration.
• Further research is needed to optimize BMP delivery for sustained bone formation.
• Gradual release of BMP from 3D reservoirs on implants is preferred to mitigate side effects like inflammation and graft failure.