Related Experiment Video
Updated: Feb 25, 2026

Author Spotlight: Investigating Angiogenesis Through Challenges and Innovations in Assay Development
Published on: May 31, 2024
Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
Francesco Paolo Cantatore1, Nicola Maruotti1, Addolorata Corrado1
1Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, Italy.
Abstract:
Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.
More Related Videos
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Mechanism of Angiogenesis
Overview of Cell-Matrix Interactions

