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Infectivity in bone marrow from sporadic CJD patients
Alvina Huor1, Jean Yves Douet1, Caroline Lacroux1
1UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, France.
The Journal of Pathology
|August 10, 2017
Summary
Prion infectivity, previously thought confined to the brain in sporadic Creutzfeldt-Jakob disease (sCJD), was found in high levels in bone marrow. This discovery may explain blood-borne prion transmission in sCJD patients.
Area of Science:
- Neuroscience
- Pathology
- Infectious Diseases
Background:
- Prion infectivity has been detected in the blood of sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD) patients.
- In vCJD, widespread peripheral prion distribution explains blood infectivity.
- In sCJD, prions are mainly localized to the central nervous system.
Purpose of the Study:
- To investigate the presence of prion infectivity in bone marrow of sCJD patients.
- To determine if bone marrow harbors prion infectivity in sCJD.
Main Methods:
- Bioassays were performed using transgenic mice expressing human prion protein.
- Bone marrow samples were collected post-mortem from sCJD patients.
Main Results:
- High levels of prion infectivity were detected in bone marrow from seven out of eight sCJD cases.
- This indicates a wider distribution of prions in sCJD than previously thought.
Conclusions:
- Bone marrow may be a significant reservoir for prion infectivity in sCJD.
- Findings suggest potential implications for iatrogenic transmission risks of sCJD.
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