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Updated: Feb 25, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
[Clinical and morphological characteristics of gastrointestinal stromal tumors]
D D Khalikov1, F Sh Akhmetzyanov2, S V Petrov2
1Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia; Republican Clinical Oncology Dispensary, Ministry of Heath of the Republic of Tatarstan, Kazan, Russia.
Abstract:
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Despite this, GISTS comprise about 2% in the structure of digestive tract cancers. They are usually localized in the stomach; however, they can be found in the small intestine and more rarely in the colon and esophagus. Although approximately 70% of the GISTs consist predominantly of spindle cells; the epithelioid cell tumors represent 20% of cases; there are also mixed variants. This variability in the morphological structure of GISTs complicates their diagnosis.
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