Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3-Aryl Phthalides
Marina Sicignano1, Antonella Dentoni Litta1, Rosaria Schettini1
1Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno , Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy.
Abstract:
The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.
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