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MicroRNA-150 as a Potential Biomarker in Diagnosis of Cancer: a Meta-Analysis

Jin Yan, Xuan Li, Lei Peng

    Clinical Laboratory
    |August 10, 2017
    PubMed
    Abstract

    Insights

    MicroRNA (miR)-150 shows potential as a noninvasive biomarker for various cancers. This meta-analysis confirms its diagnostic value, with high sensitivity and specificity for cancer detection.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biomarker Discovery

    Background:

    • MicroRNAs (miRNAs) play a role in human cancer development.
    • Previous research on circulating miR-150 levels and cancer risk yielded inconsistent results.

    Purpose of the Study:

    • To evaluate the diagnostic accuracy of miR-150 as a biomarker for human cancers.
    • To consolidate existing evidence through a meta-analysis.

    Main Methods:

    • A systematic literature search was conducted across PubMed, Embase, and Web of Science.
    • Keywords used included "miR-150" and "human cancer".
    • Diagnostic value was assessed using pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC).

    Main Results:

    • The meta-analysis demonstrated a pooled sensitivity of 80% and specificity of 81% for miR-150.
    • The diagnostic odds ratio (DOR) was 16.47.
    • The area under the curve (AUC) was 0.86, indicating good diagnostic performance.

    Conclusions:

    • Circulating miR-150 shows promise as a noninvasive tumor marker for multiple human cancers.
    • Further large-scale studies are warranted to validate these findings.

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