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A 3-Month-Old Child with Acute Gastroenteritis with Enterovirus D68 Detected from Stool Specimen
Insights
Enterovirus D68 (EV-D68), typically causing respiratory illness, was identified as the sole cause of acute gastroenteritis in a 3-month-old infant. This case report highlights a potential link between EV-D68 and gastrointestinal symptoms.
Area of Science:
- Virology
- Pediatrics
- Infectious Diseases
Background:
- Enterovirus D68 (EV-D68) is a known pathogen responsible for respiratory illnesses, ranging from mild to severe.
- EV-D68 has been associated with sporadic cases and outbreaks of respiratory disease.
Observation:
- A case report details a 3-month-old infant presenting with acute gastroenteritis in Japan.
- Diagnostic testing of the infant's stool sample revealed the presence of enterovirus.
- Sequence analysis identified the specific strain as EV-D68 clade B3.
Findings:
- Multiplex RT-PCR screening confirmed enterovirus as the only detected diarrheal virus.
- Sequence analysis of the viral protein 1 gene definitively identified EV-D68 clade B3.
Implications:
- This case provides evidence supporting a potential association between EV-D68 infection and acute gastroenteritis in pediatric patients.
- The findings may broaden the understanding of EV-D68's clinical manifestations beyond respiratory symptoms.
- Further research is warranted to explore the role of EV-D68 in gastrointestinal disease.
Abstract:
Enterovirus D68 (EV-D68) is known to be causative agent of mild to severe upper and lower respiratory illnesses in sporadic cases and outbreaks. We present a case report of a 3-month-old child with acute gastroenteritis who visited a pediatric clinic in Kyushu area in Japan in 2015. A stool sample collected from the patient was screened for diarrheal viruses by multiplex RT-PCR. The result showed that the sample was positive only for enterovirus, and EV-D68 clade B3 was identified by sequence analysis of the viral protein 1 gene. This study supports an association between EV-D68 infection and acute gastroenteritis.
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