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Pulmonary oxidative stress in diabetic rats exposed to hyperoxia
Letícia Alves Paiva1, Iandara Schettert Silva2, Albert Schiaveto de Souza3
1Fellow Master degree, Postgraduate Program in Health and Development, West Central Region, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil. Scientific and intellectual content of the study, manuscript preparation and writing.
Purpose::
To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes.
Methods::
Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed: 21%, 50%, 75% and 100% (hyperoxia). In each group five animals were randomly induced to diabetes by means of at a dose of 55 mg/kg of streptozotocin (STZ).
Results::
Seventy two hours after diabetes induction, a significant difference was seen in blood glucose in the experimental groups in comparison with the control. In the experimental groups a significant difference was observed in the concentration of malondialdehyde (MDA) in lung tissue and blood plasma (p<0.05), except the 50% group. In the control group, significant differences in the MDA concentration in plasma and lung tissue were also observed (p<0.05), except the 75% group. The MDA concentration in lung tissue in comparison with the diabetic and non-diabetic groups showed a significant difference in the 21% group; however, no difference was seen in the 75 and 100% groups.
Conclusion::
In diabetic animals high oxygen concentrations (75 and 100%) do not appear to exert deleterious effects on lipid peroxidation in lung tissue.
