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Updated: Feb 25, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
Role of ATP-Sensitive Potassium Channels in Remote Ischemic Preconditioning Induced Tissue Protection
Sapna Aggarwal1, Puneet Kaur Randhawa1, Nirmal Singh1
11 Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, India.
Abstract:
Remote ischemic preconditioning (RIPC) is an innovative treatment strategy that alleviates ischemia-reperfusion injury, whereby short episodes of regional ischemia and reperfusion delivered to remote organs including hind limb, kidney and intestine, and so on provide protection to the heart. The RIPC is known to reduce infarct size, serum levels of cardiac enzymes, and myocardial dysfunction in various animal species as well as in patients. There have been a large number of studies suggesting that the ATP-sensitive potassium channels (KATP channel) play a significant role as a mediator or end effector in RIPC. The present review discusses the role of KATP channels and possible mechanisms in RIPC-induced cardioprotection.
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