Lactational and clear cell changes of the breast in nonlactating, nonpregnant women

Secretory changes that occurred in the breasts of 32 women who were not pregnant or lactating were reviewed. These changes took two forms, with partial or complete involvement of one or more lobules. The more frequently occurring focal lactating effect was observed in 23 patients. The second form, a marked clearing of the cytoplasm within acinar cells, occurred in nine patients. Both patterns were present simultaneously in 2 of the 32 patients. Hormonal, anti-psychotic, and anti-hypertensive medications appear to correlate with the lactational change.