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Related Experiment Video

Updated: Feb 24, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
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* Animal Models for Periodontal Tissue Engineering: A Knowledge-Generating Process.

Karim M Fawzy El-Sayed1,2, Christof E Dörfer2

  • 11 Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University , Giza, Egypt .

Tissue Engineering. Part C, Methods
|August 11, 2017
PubMed
Summary
This summary is machine-generated.

Periodontal regeneration aims to restore damaged tooth-supporting tissues. This review examines tissue-engineering strategies and animal models for achieving functional periodontal regeneration, a key goal in periodontology.

Keywords:
animalguided tissue regenerationperiodontaltissue engineering

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Area of Science:

  • Periodontology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • The human periodontium is crucial for tooth support and homeostasis.
  • Chronic periodontitis causes irreversible damage to periodontal tissues.
  • Current treatments focus on repair, not complete regeneration.

Purpose of the Study:

  • To review current periodontal regeneration strategies using tissue engineering.
  • To evaluate experimental animal models for periodontal regeneration research.
  • To assess knowledge gained from in vivo animal studies, particularly large animal models.

Main Methods:

  • Literature review of tissue-engineering concepts in periodontology.
  • Analysis of experimental animal models, including defect induction and classification.
  • Evaluation of in vivo studies focusing on periodontal regeneration outcomes.

Main Results:

  • Tissue engineering offers promising avenues for periodontal regeneration.
  • Standardized animal models are essential for reproducible research.
  • Large animal models provide valuable insights into human periodontal regeneration.

Conclusions:

  • Complete periodontal regeneration remains a significant challenge.
  • Advancements in tissue engineering and animal models are critical for progress.
  • Further research is needed to translate findings into clinical applications for periodontal regeneration.