Evolutionary impact of copy number variation rates
Related Experiment Video
Updated: Feb 24, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
Published on: February 17, 2017
1Institute for Integrative Systems Biology, CSIC-UV, 46980, Paterna, Spain. guillermo.rodrigo@csic.es.
Objective:
Copy number variation is now recognized as one of the major sources of genetic variation among individuals in natural populations of any species. However, the relevance of these unexpected observations goes beyond diagnosing high diversity.
Results:
Here, it is argued that the molecular rates of copy number variation, mainly the deletion rate upon variation, determine the evolutionary road of the genome regarding size. Genetic drift will govern this process only if the effective population size is lower than the inverse of the deletion rate. Otherwise, natural selection will do.
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