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Published on: November 16, 2012
Metal Ion-Triggered Collapsed Hydrogels as Materials for Bacterial Population Control
Danniel Gee1, Roser Montagud-Martínez2, Rosa Adam1
1Department of Organic Chemistry, Faculty of Chemistry, University of Valencia, Burjassot46100, Valencia, Spain.
ACS Applied Bio Materials
|August 10, 2026
Summary
We developed metal ion-triggered collapsed hydrogels (MitCH) from poly(vinyl alcohol) (PVA)-borate. These robust materials release copper ions in biological media, inhibiting bacterial growth.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Polymer Chemistry
Background:
- Hydrogels are versatile soft materials with tunable properties.
- Poly(vinyl alcohol) (PVA)-borate hydrogels are widely used in various applications.
- Controlling hydrogel properties and functionality is crucial for advanced applications.
Purpose of the Study:
- To describe a novel metal ion-induced collapse phenomenon in PVA-borate hydrogels.
- To develop metal ion-triggered collapsed hydrogels (MitCH) with enhanced properties.
- To explore the potential of MitCH materials for controlled antimicrobial applications.
Main Methods:
- Investigated the collapse of PVA-borate hydrogels induced by Cu2+ cations.
- Analyzed material composition using elemental and ICP analyses.
- Characterized structural properties using electron paramagnetic resonance (EPR).
- Evaluated the environmental responsiveness and antimicrobial activity of MitCH materials.
Main Results:
- PVA-borate hydrogels collapse abruptly upon increasing Cu2+ concentration, forming robust solids with high copper loading (up to ~14% wt).
- Collapse is pH-neutral and dependent on copper concentration, counterion, and PVA characteristics.
- MitCH materials are stable in water but dissolve in biological media, releasing copper ions.
- Demonstrated controlled inhibition of Escherichia coli growth using MitCH materials.
Conclusions:
- MitCH materials offer a promising platform for antimicrobial applications.
- These materials combine simple preparation, high metal loading, stability, and responsive release.
- The findings open new avenues for developing smart hydrogel-based delivery systems.
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