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UV imaging in pharmaceutical analysis.

Jesper Østergaard1

  • 1Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Journal of Pharmaceutical and Biomedical Analysis
|August 12, 2017
PubMed
Summary
This summary is machine-generated.

UV imaging offers precise measurements for pharmaceutical analysis, aiding in drug release and dissolution studies. This technology provides real-time insights into drug behavior during formulation development.

Keywords:
DiffusionDissolution imagingDissolution testingUV imagingin vitro release

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Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • UV imaging provides spatially and temporally resolved absorbance measurements.
  • It is highly useful in pharmaceutical analysis, particularly for in vitro dissolution and release testing.

Purpose of the Study:

  • To review the principles and applications of UV imaging in pharmaceutical analysis.
  • To summarize its use in dissolution rate determination, excipient compatibility, and parenteral drug release studies.

Main Methods:

  • Review of UV imaging technology principles.
  • Summary of applications in pharmaceutical dissolution and release testing.

Main Results:

  • UV imaging is valuable for intrinsic dissolution rate determination.
  • It aids in excipient compatibility studies and in vitro release characterization of parenteral formulations.
  • The technology enables real-time monitoring of swelling, precipitation, diffusion, and partitioning.

Conclusions:

  • UV imaging offers significant potential for advancing drug dissolution and release studies.
  • It provides new insights into formulation development processes.
  • Emerging instrumentation promises further advancements in UV imaging applications.