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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Updated: Feb 24, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

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Cutaneous Squamous Cell Carcinoma.

Vishwas Parekh1, John T Seykora2

  • 1Department of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.

Clinics in Laboratory Medicine
|August 14, 2017
PubMed
Summary
This summary is machine-generated.

Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. This overview details cSCC, its precursors, and variants, focusing on histopathology and molecular causes for accurate diagnosis.

Keywords:
Acantholytic squamous cell carcinomaActinic keratosisDesmoplastic squamous cell carcinomaKeratoacanthomaPathogenesisSpindle cell squamous cell carcinomaSquamous cell carcinoma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous squamous cell carcinoma (cSCC) is the second most common global malignancy.
  • cSCC typically affects elderly individuals with chronic sun-damaged skin.
  • Accurate differentiation from benign lesions and identification of high-risk features are critical.

Purpose of the Study:

  • To provide an updated overview of cutaneous SCC.
  • To discuss precursor lesions and histologic variants of cSCC.
  • To emphasize histopathologic features and molecular pathogenesis.

Main Methods:

  • Review of current literature on cSCC.
  • Analysis of histopathologic features.
  • Discussion of molecular pathogenesis pathways.

Main Results:

  • cSCC arises from aberrant keratinocyte proliferation.
  • Key histopathologic features aid in differentiating cSCC from benign lesions.
  • Molecular pathways contribute to cSCC development.

Conclusions:

  • Understanding cSCC's histopathology and molecular basis is crucial for diagnosis and management.
  • Identification of precursor lesions and variants improves patient outcomes.
  • This review offers a comprehensive perspective for pathologists.