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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Primary Cutaneous B-cell Lymphomas.

Charity B Hope1, Laura B Pincus2

  • 1Department of Pathology, UCSF Dermatopathology Section, University of California, San Francisco, 1701 Divisidero Street, Room 280, San Francisco, CA 94115, USA.

Clinics in Laboratory Medicine
|August 14, 2017
PubMed
Summary
This summary is machine-generated.

Primary cutaneous B-cell lymphomas (PCBCLs) are rare skin cancers. This review details the clinical, histopathologic, immunophenotypic, and molecular features of the three main PCBCL subtypes.

Keywords:
Intravascular diffuse large B-cell lymphomaLeg typePrimary cutaneous B-cell lymphomaPrimary cutaneous diffuse large B-cell lymphomaPrimary cutaneous follicle center lymphomaPrimary cutaneous marginal zone lymphoma

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • B-cell lymphomas constitute 20-25% of primary cutaneous lymphomas.
  • The majority of primary cutaneous B-cell lymphomas (>99%) fall into three main diagnostic categories.
  • Rarer forms like intravascular large B-cell lymphoma are also considered.

Purpose of the Study:

  • To present a comprehensive overview of primary cutaneous B-cell lymphomas.
  • To detail the clinical, histopathologic, immunophenotypic, and molecular characteristics of key subtypes.
  • To provide clarity on the diagnostic entities within this group.

Main Methods:

  • Review of clinical presentations.
  • Analysis of histopathologic findings.
  • Evaluation of immunophenotypic and molecular data.

Main Results:

  • Detailed descriptions of primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type.
  • Highlighting distinguishing features for each entity.
  • Brief discussion of intravascular large B-cell lymphoma.

Conclusions:

  • Accurate diagnosis of primary cutaneous B-cell lymphomas relies on integrated clinicopathologic assessment.
  • Understanding the distinct features of each subtype is crucial for appropriate patient management.
  • This review serves as a guide to the primary cutaneous B-cell lymphoma landscape.