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Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements
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Vegetable-derived bioactive nitrate and cardiovascular health
Catherine P Bondonno1, Lauren C Blekkenhorst2, Alex H Liu2
1School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital Unit, Perth, WA, Australia.
Molecular Aspects of Medicine
|August 14, 2017
Summary
Dietary nitrate from vegetables boosts nitric oxide (NO) for heart health. This review explores nitrate
Area of Science:
- Cardiovascular Science
- Nutritional Biochemistry
- Phytochemical Research
Background:
- Dietary nitrate is a key phytochemical with recognized cardioprotective effects.
- The enterosalivary nitrate-nitrite-nitric oxide (NO) pathway highlights nitrate's role in cardiovascular health.
- Exogenous NO administration and dietary nitrate show similar beneficial cardiovascular effects.
Purpose of the Study:
- To review evidence on dietary nitrate's cardioprotective effects via endogenous NO.
- To address the gap in understanding long-term cardiovascular outcomes related to dietary nitrate intake.
- To discuss factors influencing nitrate-to-nitrite-to-NO conversion and potential concerns.
Main Methods:
- Literature review of clinical trials and observational studies.
- Analysis of the enterosalivary nitrate-nitrite-nitric oxide pathway.
- Examination of evidence linking dietary nitrate to vascular health markers.
Main Results:
- Dietary nitrate intake is associated with reduced blood pressure.
- Nitrate improves endothelial function, arterial stiffness, and ischemia reperfusion.
- Evidence suggests nitrate positively impacts blood flow and platelet aggregation.
Conclusions:
- Dietary nitrate is a significant cardioprotective component of vegetable-rich diets.
- Further research is needed on long-term outcomes and potential risks of nitrate intake.
- Optimizing the nitrate-nitrite-NO pathway is crucial for cardiovascular benefits.
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