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Psychosis in Parkinson's Disease
Dominic H Ffytche1, Dag Aarsland2
1Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
International Review of Neurobiology
|August 14, 2017
Summary
Parkinson's disease psychosis (PD psychosis) is a spectrum of symptoms. Recent advances include increased recognition with disease duration, broader symptom definitions, and new treatments like pimavanserin.
Area of Science:
- Neurology
- Psychiatry
Background:
- James Parkinson's original descriptions did not emphasize psychosis, but his longitudinal view is crucial for understanding current symptoms.
- The concept of Parkinson's disease psychosis (PD psychosis) emerged from focusing on disease progression, unifying a spectrum of positive symptoms.
- The 2007 criteria for PD psychosis spurred significant research into its clinical aspects, mechanisms, and treatments.
Purpose of the Study:
- To review the evolving understanding and literature of Parkinson's disease psychosis (PD psychosis).
- To highlight key recent developments in the study and management of PD psychosis.
Main Methods:
- Literature review of clinical aspects, mechanisms, and treatment of PD psychosis.
- Analysis of recent developments including prevalence, symptom broadening, risk factors, biomarkers, and therapeutic approvals.
Main Results:
- PD psychosis prevalence increases with disease duration.
- Symptoms included in PD psychosis have broadened, with better characterization of risk factors for visual and cognitive dysfunction.
- Evidence includes imaging biomarkers and the US approval of pimavanserin for PD psychosis treatment.
Conclusions:
- Accumulating evidence on PD psychosis raises new research questions for improved clinical management.
- PD psychosis may serve as a biomarker for Parkinson's disease stage and progression.
- Future research promises a better understanding of PD psychosis and its role in Parkinson's disease.
Keywords:
DelusionIllusionMisidentificationNeuropsychiatryPareidoliaPassagePresenceVisual hallucinationMore Related Videos
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