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Neutrophils, NETs, NETosis - old or new factors in sepsis and septic shock?
1Department of Anaesthesiology and Intensive Care, 4th Military Hospital of Wroclaw Faculty of Health Science, Wroclaw Medical University, Poland. starling@poczta.onet.pl.
Abstract:
Neutrophils are an key part of the innate immune system in the host's defences against pathogens. Circulating neutrophils are recruited at the sites of infection or sterile inflammation in response to pathogen and host-derived inflammatory mediators. In addition to phagocytosis and degranulation, neutrophils display the release of NETs in order to restrain infection. NETs are able to entrap and kill microbes, and display proinflammatory and prothrombotic properties.
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