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CoMIC, the hidden dynamics of mitochondrial inner compartments

Bongki Cho1, Woong Sun2

  • 1Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea.

BMB Reports
|August 15, 2017
PubMed

Insights

Mitochondrial division involves a newly discovered process called Constriction of the Mitochondrial Inner Compartment (CoMIC). This transient constriction of the inner mitochondrial membrane precedes outer membrane division, clarifying mitochondrial morphology regulation.

Area of Science:

  • Cell Biology
  • Mitochondrial Dynamics
  • Molecular Mechanisms

Background:

  • Mitochondria possess distinct outer (OMM) and inner membranes (IMM) with unique functions.
  • Mitochondrial morphology is regulated by coordinated fission and fusion of OMM and IMM.
  • The mechanism of IMM structural changes during division was previously unclear.

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