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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Related Experiment Video

Updated: Feb 24, 2026

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Recent progresses in biomedical applications of aptamer-functionalized systems.

Fei Ding1, Yangguang Gao2, Xianran He2

  • 1Wuhan Economic and Technological Development Zone, Institute for Interdisciplinary Research, Jianghan University, Wuhan 430056, PR China; Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056, PR China.

Bioorganic & Medicinal Chemistry Letters
|August 15, 2017
PubMed
Summary

Aptamer-functionalized systems show promise in biosensing and targeted therapies. Further research is needed to overcome challenges for clinical and industrial applications.

Keywords:
AptamerAptamer-functionalized systemsBiosensingCancer cell imagingGene therapyTargeted drug delivery

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Nanotechnology

Background:

  • Aptamers, or "chemical antibodies," are developed using systematic evolution of ligands by exponential enrichment (SELEX).
  • These molecules offer specific targeting, high affinity, low immunogenicity, and ease of modification.
  • Aptamer-functionalized systems have demonstrated potential across various applications.

Purpose of the Study:

  • To review recent advancements in aptamer-functionalized systems.
  • To highlight applications in biosensing, targeted drug delivery, gene therapy, and cancer cell imaging.
  • To discuss current challenges and future prospects for aptamer commercialization.

Main Methods:

  • Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer screening.
  • Review of literature on aptamer-functionalized systems in diverse applications.
  • Analysis of challenges hindering clinical and industrial adoption.

Main Results:

  • Aptamer-functionalized systems show favorable results in biosensing, drug delivery, gene therapy, and cancer imaging.
  • Significant progress has been made in harnessing aptamer properties for advanced applications.
  • Commercialization and widespread clinical use remain limited.

Conclusions:

  • Aptamer-functionalized systems hold considerable potential for various biomedical fields.
  • Overcoming current challenges is crucial for translating research into clinical and industrial products.
  • Future research should focus on improving system design and addressing commercialization hurdles.