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Pulmonary function in patients with eosinophilic chronic rhinosinusitis.

Kensuke Uraguchi1, Shin Kariya2, Seiichiro Makihara1

  • 1Department of Otolaryngology-Head and Neck Surgery, Kagawa Rosai Hospital, Kagawa, Japan.

Auris, Nasus, Larynx
|August 15, 2017
PubMed
Summary

Eosinophilic chronic rhinosinusitis (ECRS) patients show impaired pulmonary function, specifically peripheral airway obstruction. Early monitoring for lung disease is crucial for ECRS patients.

Keywords:
AsthmaChronic obstructive pulmonary diseaseLung functionRhinitisSinusitis

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Area of Science:

  • Respiratory Medicine
  • Immunology
  • Pulmonology

Background:

  • Upper and lower airway diseases are closely linked.
  • Chronic rhinosinusitis (CRS) often co-occurs with lung conditions like asthma and COPD.
  • Eosinophilic CRS (ECRS) is a severe CRS subtype lacking pulmonary function data.

Purpose of the Study:

  • To compare pulmonary function between ECRS and non-ECRS patients.
  • To identify clinical factors associated with pulmonary function in ECRS patients.

Main Methods:

  • Pulmonary function tests were conducted on 53 ECRS with asthma, 58 ECRS without asthma, and 30 non-ECRS patients.
  • Diagnoses followed EPOS 2012 and JESREC criteria.
  • Correlations between pulmonary function and radiographic severity, blood eosinophils, IgE, and nasal polyp eosinophilia were analyzed.

Main Results:

  • ECRS patients exhibited significantly affected pulmonary function.
  • Peripheral airway obstruction was more pronounced in ECRS patients compared to non-ECRS patients.

Conclusions:

  • ECRS is associated with latent obstructive lung function changes.
  • Close monitoring for lung diseases is recommended for ECRS patients.