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Updated: Feb 24, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
Determination of Fibrinogen and Thrombin Time (TT)
1Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202, Cracow, Poland. mmundas@cyf-kr.edu.pl.
Abstract:
Fibrinogen is measured in plasma most commonly using the Clauss method, based on the comparison of thrombin clotting times of dilutions of plasma against a plasma standard. Thrombin time (TT) is a coagulation assay, which reflects the conversion of fibrinogen to fibrin after addition of thrombin reagent. Measurement of clottable fibrinogen and TT allows detecting inborn (congenital) and acquired qualitative and quantitative disorders of fibrinogen that can lead to thrombotic or bleeding events.
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