COP1 integrates light signals to ROP2 for cell cycle activation
Wenguo Cai1, Xiaojuan Li2,3, Yanlin Liu2,3
1a Horticultural Plant Biology and Metabolomics Center, Haixia Institute of Science and Technology , Fujian Agriculture and Forestry University , Fujian Province , P. R. China.
Plant Signaling & Behavior
|August 15, 2017
Summary
Plants adapt to light by regulating cell division. Constitutive Photomorphogenesis 1 (COP1) controls this process by influencing auxin, ROP2, and TOR signaling pathways, crucial for shoot apex development.
Area of Science:
- Plant Biology
- Molecular Plant Physiology
Background:
- Plant shoot apex cell division is vital for adaptation to environmental cues.
- Light and sugar signaling are essential for activating cell division.
- Previous work identified light-to-auxin-to-ROP2-to-TOR signaling pathway.
Purpose of the Study:
- To elucidate the upstream regulators of the auxin-ROP2-TOR signaling pathway.
- To investigate the role of Constitutive Photomorphogenesis 1 (COP1) in light-mediated cell division.
Main Methods:
- Investigated the interaction between COP1, auxin, ROP2, and TOR.
- Utilized auxin biosynthesis and TOR chemical inhibitors (yucasin, torin2).
- Observed true leaf development in cop1-6 mutants under varying light conditions.
Main Results:
- COP1 acts upstream of ROP2, regulating its activity in an auxin-dependent manner.
- COP1 influences Target of Rapamycin (TOR) kinase activity.
- Auxin and TOR inhibitors impair leaf development in cop1-6 mutants, even in darkness.
Conclusions:
- COP1 integrates light signals into the auxin-ROP2-TOR pathway.
- This pathway is critical for light-regulated cell division and plant development.
Related Concept Videos
01:23Negative Regulator Molecules
38.6K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
02:39Positive Regulator Molecules
7.0K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
7.0K
01:45Positive Regulator Molecules
136.7K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
136.7K
01:28The Cell Cycle Control System
5.9K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.9K
02:11The Cell Cycle Control System
14.6K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.6K
01:25Cell Signaling in Plants
6.7K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.7K