Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Keeping the ICRP recommendations fit for purpose.

Journal of radiological protection : official journal of the Society for Radiological Protection·2021
Same author

Origin of the quasi-quantized Hall effect in ZrTe<sub>5</sub>.

Nature communications·2021
Same author

Test of Lepton-Flavor Universality in B→K^{*}ℓ^{+}ℓ^{-} Decays at Belle.

Physical review letters·2021
Same author

Evidence for X(3872)→J/ψπ^{+}π^{-} Produced in Single-Tag Two-Photon Interactions.

Physical review letters·2021
Same author

Search for Axionlike Particles Produced in e^{+}e^{-} Collisions at Belle II.

Physical review letters·2020
Same author

Measurement of R(D) and R(D^{*}) with a Semileptonic Tagging Method.

Physical review letters·2020
Same journal

MiR-335-3p Alleviates Adipogenesis and Inflammation in Bone Marrow-Derived Mesenchymal Stem Cells in Osteoporotic Fractures.

Folia biologica·2026
Same journal

Research on the Diagnostic Potential of miR-383-5p in Rheumatoid Arthritis.

Folia biologica·2026
Same journal

The Predictive Value of NLRP3-Mediated Inflammatory Factor Production for Abnormal Liver Function in Pregnant Women with Hepatitis B.

Folia biologica·2026
Same journal

Mechanism Study and Analysis of Correlation between miR-409-3p and Post-Stroke Cognitive Impairment.

Folia biologica·2026
Same journal

Correlation between circ_0092576 and Arterial Stenosis Severity and Inflammatory Status in Patients with Coronary Heart Disease and Its Clinical Value.

Folia biologica·2026
Same journal

Intravitreal Application of Mesenchymal Stem Cell By-Products Does Not Ameliorate Experimental Autoimmune Uveitis.

Folia biologica·2026
See all related articles

Related Experiment Video

Updated: Feb 24, 2026

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ
08:44

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

Published on: June 5, 2018

73.0K

Microglia: Physiological Functions Revealed through Morphological Profiles.

K Cho1, G-E Choi2

  • 1Granduate School of International Studies, Dong-A University, Busan, Republic of Korea.

Folia Biologica
|August 15, 2017
PubMed
Summary
This summary is machine-generated.

Microglia are key immune cells in the brain. This review details their diverse phenotypes and molecular profiles, aiding research into brain injury and disease treatments.

More Related Videos

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.8K
Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium
12:00

Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium

Published on: March 9, 2018

17.1K

Related Experiment Videos

Last Updated: Feb 24, 2026

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ
08:44

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

Published on: June 5, 2018

73.0K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.8K
Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium
12:00

Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium

Published on: March 9, 2018

17.1K

Area of Science:

  • Neuroimmunology
  • Cellular Biology

Background:

  • Microglia are the primary immune cells of the central nervous system (CNS).
  • Activated microglia exhibit morphological changes (ramified to amoeboid) and functional shifts, including phagocytosis and cytokine release.

Purpose of the Study:

  • To review microglial phenotypes and their functional roles in the CNS.
  • To emphasize the molecular profiles associated with different microglial states.
  • To highlight the importance of understanding microglial functions in health and disease.

Main Methods:

  • Literature review of microglial biology.
  • Analysis of molecular signatures of microglial phenotypes.
  • Synthesis of current knowledge on microglial roles in CNS physiology and pathology.

Main Results:

  • Microglia display a spectrum of phenotypes crucial for CNS homeostasis and response to injury.
  • Distinct molecular profiles characterize different microglial activation states.
  • Phagocytosis and pro-inflammatory cytokine release are key functions of activated microglia.

Conclusions:

  • Understanding microglial phenotypes and molecular profiles is essential for elucidating their roles in the CNS.
  • This knowledge can advance research in brain injury and neurodegenerative diseases.
  • Targeting microglial functions offers potential therapeutic strategies for CNS disorders.