Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aging, cellular senescence, and Parkinson's disease: A different interpretation of the same evidence.

Parkinsonism & related disorders·2026
Same author

Microstimulation of the human dopaminergic midbrain enhances outcome-related happiness and reduces loss seeking.

bioRxiv : the preprint server for biology·2026
Same author

Sustained Effects of a 6-Week Resiliency Program for Women with Metastatic Breast Cancer: A Brief Report of a Clinical Trial.

Journal of palliative medicine·2026
Same author

Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease.

JAMA neurology·2025
Same author

Cognitive Assessment in Adults With Adrenal Cortisol Insufficiency: Challenges and Opportunities.

Endocrine reviews·2025
Same author

Comparing Functional Response in Patients With and Without COVID-19 Admitted to Inpatient Rehabilitation: A Retrospective Study.

American journal of physical medicine & rehabilitation·2025

Related Experiment Video

Updated: Feb 24, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.2K

Deep Brain Stimulation and Nonmotor Symptoms.

Elliot Hogg1, Jeffrey Wertheimer1, Sarah Graner1

  • 1Cedars-Sinai Medical Center, Los Angeles, CA, United States.

International Review of Neurobiology
|August 15, 2017
PubMed
Summary

Deep brain stimulation (DBS) offers benefits for Parkinson's disease (PD) motor symptoms and may improve nonmotor symptoms (NMS). Further research is needed to confirm DBS efficacy for various NMS in PD patients.

Keywords:
Deep brain stimulationGlobus pallidumNonmotor symptomsParkinson's diseaseSubthalamic nucleus

More Related Videos

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

11.3K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.9K

Related Experiment Videos

Last Updated: Feb 24, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.2K
Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

11.3K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.9K

Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) is a primary treatment for advanced Parkinson's disease (PD), yielding excellent motor outcomes.
  • Established targets include the subthalamic nucleus and globus pallidus internus.
  • DBS's role in managing nonmotor symptoms (NMS) in PD is less understood but potentially significant.

Purpose of the Study:

  • To assess the global nonmotor outcomes of DBS in Parkinson's disease.
  • To review the impact of DBS on specific NMS categories: neurobehavioral, autonomic, sleep, and sensory symptoms.
  • To evaluate the evidence for DBS as a treatment for NMS in PD.

Main Methods:

  • Review of existing clinical scales and questionnaires measuring NMS in PD patients undergoing DBS.
  • Analysis of studies examining DBS effects on neurobehavioral, autonomic, sleep, and sensory symptoms.
  • Synthesis of current literature on DBS for NMS in Parkinson's disease.

Main Results:

  • DBS demonstrates an overall positive impact on most nonmotor symptoms in Parkinson's disease patients.
  • Benefits may arise directly from brain stimulation or indirectly from motor improvements and reduced medication.
  • Specific NMS categories reviewed include cognitive, neuropsychiatric, autonomic (e.g., orthostatic hypotension), sleep (e.g., insomnia), and sensory (e.g., pain) symptoms.

Conclusions:

  • Deep brain stimulation shows promise for managing a range of nonmotor symptoms in Parkinson's disease.
  • The current evidence base is limited by small sample sizes and a lack of large, controlled studies specifically designed for NMS.
  • Further research is warranted to fully elucidate the efficacy and mechanisms of DBS for nonmotor aspects of Parkinson's disease.