Related Experiment Video
Updated: Feb 24, 2026
03:52
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
1.4K
Vitamin D and osteosarcopenia: an update from epidemiological studies
Olivier Bruyère1, Etienne Cavalier, Jean-Yves Reginster
1aDepartment of Public Health, Epidemiology, and Health Economics bDepartment of Clinical Chemistry, CHU de Liège, University of Liège, Liège, Belgium.
Current Opinion in Clinical Nutrition and Metabolic Care
|August 15, 2017
Summary
This review explores the link between osteoporosis and sarcopenia, finding vitamin D may play a role. More research is needed to confirm its impact on osteosarcopenia treatment.
Area of Science:
- Gerontology
- Bone and Muscle Health
- Nutritional Epidemiology
Background:
- Osteoporosis and sarcopenia are significant public health concerns.
- The combined condition, osteosarcopenia, lacks a universally accepted definition.
- Existing research suggests a relationship between muscle and bone health.
Purpose of the Study:
- To review recent epidemiological studies on osteoporosis and sarcopenia.
- To assess the influence of vitamin D status and supplementation on related health outcomes.
- To evaluate the role of vitamin D in osteosarcopenia.
Main Methods:
- Systematic review of epidemiological studies.
- Analysis of observational data on muscle and bone health.
- Examination of vitamin D supplementation trial results.
Main Results:
- Lower vitamin D levels are common in individuals with bone or muscle wasting.
- Studies show a relationship between muscle and bone health.
- Vitamin D supplementation effects are inconsistent, possibly due to study variations; positive results seen in vitamin D-deficient individuals and with cautious dosing.
Conclusions:
- Further observational and interventional studies are required.
- The precise role of vitamin D in osteosarcopenia's development and treatment needs confirmation.
More Related Videos
Related Concept Videos
01:25Role of Vitamins in Maintaining Bone Health
5.8K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.8K
01:29Bone Disorders
5.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.7K
01:31Osteoclasts in Bone Remodeling
4.4K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.4K
01:21Skeleton and Calcium Homeostasis
6.2K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.2K
01:23Role of Skin in Vitamin D Synthesis
8.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.3K
01:31Essential Minerals for Bone Health
6.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.8K