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Generalized Lymph Node FDG Uptake as the First Manifestation of Systemic Lupus Erythematosus
Antoine Girard1, Jessica Ohnona, Jean-François Bernaudin
1From the *Department of Nuclear Medicine, Tenon Hospital, Assistance Publique-Hôpitaux de Paris; and Departments of †Nuclear Medicine, ‡Pathology, and §Internal Medicine, Tenon University Hospital, Paris, France.
Abstract:
We report 2 cases of young patients referred for FDG PET/CT for peripheral lymphadenopathy and moderate fever associated with pericarditis in 1 patient and glomerulonephritis in the other patient. FDG PET/CT showed a very similar appearance in these 2 patients, with highly avid lymph nodes with axillary predominance and diffuse FDG uptake in spleen and bone marrow. Systemic lupus erythematosus with an unusual presentation of generalized lymphadenopathy was diagnosed in both patients. This FDG distribution pattern should be kept in mind when PET is performed for etiological investigation of fever of unknown origin.
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